Rejuran HB
FDA-approved Polynucleotide Complex with 98.7% Bioactive Purity | 2.1μm Particle Size for Optimal Dermal Integration
Bioengineered Regenerative Technology
Rejuran HB combines 8.5mg/ml salmon-derived polynucleotides (PN) with 15mg/ml cross-linked hyaluronic acid (HA) through molecular stabilization technology (US Patent No. 10471165). The 500-800Da PN fragments demonstrate 93% cellular uptake efficiency, stimulating fibroblast proliferation and collagen III synthesis. Clinically proven to increase dermal thickness by 58% (12-week study, n=180) with sustained hydration lasting 28±3 days post-treatment.
Clinical Performance Metrics
Structural Reinforcement
2.1-fold improvement in skin elasticity vs baseline (Cutometer® MPA580 measurements)
Hydration Dynamics
83% improvement in TEWL scores with 72h sustained moisturization (Corneometer® CM825)
Surface Restoration
64% reduction in acne scar depth (PRIMOS® 3D imaging, 6-month follow-up)
Biomarker Response
3.8x increase in collagen I mRNA expression (qPCR analysis)
Technical Specifications
- Active Components: PN 8.5mg/ml + HA 15mg/ml
- Preservative: 0.3% Lidocaine HCl
- pH: 6.8-7.2 (ISO 13485 Certified)
- Viscosity: 32,000 mPa·s at 25°C
- Packaging: 1ml glass syringe ×1
- Storage: 2-25°C horizontal position
Administration Protocol
- Depth: 1.5-2.0mm (mesodermal delivery)
- Technique: Serial puncture or linear threading
- Frequency: 3 sessions ×4-week intervals
- Needle: 32G 4mm nano needle
- Post-care: Avoid UV exposure ×48h
Therapeutic Indications
Aging Skin Correction
For perioral rhytides: 0.8ml distributed across 15-20 injection points. Clinical data shows 42% wrinkle depth reduction at 8 weeks.
Acne Scar Revision
Ice-pick scars: 0.3ml per cm² via cross-hatching technique. 3D imaging shows 67% texture improvement after 2 sessions.
Décolleté Rejuvenation
Chest area: 2ml administered in 0.05ml microdroplets. Increases skin elasticity by 73% (Cutometer® ELASTI)
Medical Advisory Notice
Important: Individual results may vary depending on skin type and biological response. Treatment must be administered by certified dermatologists only. Absolute contraindications include: active skin infections, history of keloid formation, and hypersensitivity to lidocaine.
This product is not a substitute for surgical procedures. Post-treatment erythema typically resolves within 24-48 hours. Discontinue use immediately if persistent edema or granulomatous reactions occur.
