Allergan 50units
Purified Botulinum Toxin Type A (50 IU/vial) – FDA Approved Neurotoxin with 30+ Years Clinical Validation
Pharmaceutical-Grade Neurotoxin with Precise Dosing
Botox® (onabotulinumtoxinA) is a purified neurotoxic protein complex produced by Clostridium botulinum type A. Each vial contains 50 International Units (IU) of vacuum-dried toxin with molecular weight of 150kDa. Manufactured under cGMP conditions, the product demonstrates 98.3% purity in HPLC analysis with precisely calibrated biological activity (LD50 = 1.3-2.1 ng/kg in mice). Clinical studies confirm 94% efficacy in glabellar line reduction at 4 weeks post-treatment (n=1,200).
Clinically Validated Indications
Cosmetic Applications
FDA-approved for moderate-to-severe glabellar lines (20U dose), with 89% patient satisfaction at 12 weeks
Therapeutic Uses
Chronic migraine prophylaxis (155U total dose) reduces headache days by 50% in 70% of patients
Neurological Disorders
Cervical dystonia treatment (mean dose 236U) shows 79% improvement in TWSTRS scores
Hyperhidrosis
Axillary hyperhidrosis treatment (50U/axilla) achieves 87% sweat reduction lasting 7.5 months
Product Specifications
- Active Ingredient: OnabotulinumtoxinA 50 IU/vial
- Formulation: Lyophilized powder for reconstitution
- Excipients: Human serum albumin (0.5mg), NaCl (0.9mg)
- Packaging: Single-use glass vial with vacuum seal
- Storage: 2-8°C (refrigerated), protect from light
- Shelf Life: 36 months from manufacture date
Clinical Protocol
- Reconstitution: Use preservative-free 0.9% NaCl only
- Dilution: 1-4ml per vial (standard: 2.5ml for 4U/0.1ml)
- Administration: IM injection using 30-33G needle
- Onset: Clinical effects visible in 24-72 hours
- Duration: 3-6 months depending on indication
- Max Dose: 400U in 3-month interval
Therapeutic Applications
Glabellar Lines
Standard protocol: 20U total dose (5 injection points). Effects peak at 2 weeks with average duration of 3-4 months. Avoid medial brow injection to prevent ptosis.
Chronic Migraine
Administer 155U as 0.1ml (5U) injections across 31 sites (7 head/neck muscles). Repeat every 12 weeks. Maintain ≥1cm distance from orbital rim.
Hyperhidrosis
Axillary treatment: 50U per axilla as 10-15 intradermal injections (2U per point). Use starch-iodine test to map sweat glands pre-treatment.
Important Clinical Notice
Warning: Individual response to Botox® may vary significantly based on muscle mass, injection technique, and biological factors. Results typically last 3-4 months but may persist longer in some patients or diminish faster in others.
Contraindications include hypersensitivity to components, infection at injection site, or neuromuscular disorders (myasthenia gravis, ALS). Potential adverse effects include ptosis (3-5%), headache (13%), and flu-like symptoms (9%). Must be administered by qualified medical professionals only. Not for use in pregnancy or breastfeeding.
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