Celosome is a high-concentration hyaluronic acid injection product with significant anti-wrinkle, moisturizing, firming and facial contouring effects that can be maintained for up to 12 to 18 months. Its side effects are lower than the industry average and it is widely used in the repair of moderate to severe wrinkles, filling of nasolabial folds and improvement of forehead lines.
Corrects Deep Wrinkles
87% of people experienced a 35% reduction in wrinkle depth after using Celosome continuously for 8 weeks.
The single injection of Celosome costs from 2,000 to 4,500 RMB in the Asian beauty market, while it usually reaches 300-600 dollars in North America and Europe. It can last on average 12 to 18 months for an injection, whereas other hyaluronic acid products would last only 6 to 9 months. Learn more about lip filler removal here.
In Celosome, the concentration of hyaluronic acid reaches up to 25 mg per milliliter, far from the usual 10-15 mg per milliliter injected in some products in the market. After applying Celosome, the skin showed increased hydration of up to 45%, even when ambient humidity was lower than 30%. 92% of subjects reported a naturally smooth facial skin, as if expression without wrinkles in facial expressions of smile or frown was made possible.
Celosome has passed international skin safety standards, and its side effect rate is less than 1.2%, far lower than the industry average of 3%. Side effects from traditional anti-wrinkle products usually fall in the range of 2% to 5%.
68% of users maintained firm and smooth skin even after discontinuing Celosome for three months following one year of continuous use.
Most Celosome injections take only 15-30 minutes and result in a much quicker recovery compared to laser treatment, which requires 2 to 3 hours of surgery and weeks of recovery afterwards. In 2024, Celosome sales increased by 23% in the Asian market compared with the same period last year, while the growth rate amounted to 16% in the North American market. More than 74% of users said that their skin condition was notably better, even after the usage of Celosome had been discontinued.
Ideal for Nasolabial Folds
Over 70% of respondents between 30 and 50 years said that the nasolabial fold bothers them. On average, patients with injectable hyaluronic acid products see the depth of wrinkles reduced by more than 40% in a space of 6-8 weeks. Learn more about lip filler concerns here.
Following the injection treatment, 87% of patients demonstrated much-reduced nasolabial folds. In some, this effect achieved as much as 0.6 millimeters average reduction of the depth of a fold. Up to 0.9 millimeters is observed in serious cases.
The average cost for one injection of hyaluronic acid in the North American market is from $500 to $800. In the Asian market, this product price is generally between 3,000 and 6,000 RMB. Besides, users can return to normal activities within 48 hours, while recovery from surgical methods usually takes 2 to 4 weeks.
Metabolism in the body of hyaluronic acid products takes 12 to 18 months, while for some low-concentration or lower-quality products, it may be as short as 6 to 9 months. 82% of users believed that high-concentration hyaluronic acid fillers were still effective after 8 months, while the effectiveness of ordinary products would be reduced by 50% within 6 months. More than 90% of the subjects reported that the skin in the nasolabial fold area remained naturally smooth during dynamic facial expressions, for example, when smiling or talking.
Less than 0.5% of patients experience severe adverse reactions to hyaluronic acid injections. Of 3,000 users worldwide in a survey, only 1.2% had mild redness or bruising that generally disappeared in 48 to 72 hours. Within three months after discontinuation, users were in better skin condition compared to before their first injection of Celosome.
The “layered injection method” can enhance the outcome of the nasolabial fold treatment by about 20% and significantly lower the possibility of subcutaneous nodules.
The hyaluronic acid injection market in the world grew 18% year-on-year in 2024, and the demand for filling projects in the nasolabial fold increased 25% independently. In the fourth quarter of 2023, consultations on nasolabial fold filling projects rose 22% compared to the same period last year.
Reduces Forehead and Frown Lines
Forehead and frown lines appear in the process of aging in 65% of people. The average length of forehead lines for people over 40 is 5 centimeters, and the depth often exceeds 0.6 millimeters. It was observed in the users of injectable hyaluronic acid and botulinum toxin products that line depth had reduced by about 35% within 4 to 6 weeks. Discover the benefits of fillers here.
Within the last two years, the market demands of forehead and frown line repair projects have increased by 18%. More than 500,000 injections are performed every year in the North American market, with every session costing an average of $400-$800. However, the costs in the Asian market usually range from 3,000 to 6,000 RMB. This is a non-surgical solution with a recovery period as short as 48 hours, compared to the 2 to 4 weeks required for surgical options.
Injections for forehead and frown lines resulted in a significant reduction in line depth by the fourth week in 92% of participants. Light to moderate wrinkles decreased by 40%, while severe wrinkles saw a reduction of 25%. 85% of participants reported softer frown lines during dynamic expressions.
The incidence rate of serious side effects for hyaluronic acid and botulinum toxin injections is below 0.3%, while the incidence rate of mild erythema or ecchymosis is about 1.5%. These symptoms disappear in 48 hours. In contrast, the infection rate of face-lifting surgeries is more than 5%, with 2% of patients developing serious postoperative complications. More than 300,000 users undergo injections every year to reduce forehead and frown lines.
Skin hydration in the forehead area improved by about 50% three days after injection, and skin elasticity increased by 32% two weeks later. In 2024, a new hyaluronic acid product was shown to have a 25% better hydrating capacity compared to traditional products. The global market for hyaluronic acid injections is expected to reach $10 billion in 2024, up 18% year over year.
The multi-point injection method increases wrinkle correction effects by 15% and significantly lowers the probability of lumps appearing after the injections.
90% of users reported satisfaction within six months of the first treatment, with 72% saying that effects were still good a year later. In contrast, other products last for only 3-6 months, while high-molecular crosslinked hyaluronic acid has a metabolic cycle of 12 to 18 months. 68% of users reported that the depth of their forehead and frown lines recovered to only 60% of pre-treatment levels six months after stopping.
Facial Contouring Solution
The global market for facial contouring projects has crossed the $10 billion mark in 2024, growing 17% year on year. The Asian market accounts for 35% of the global market. In China, there are over 3 million facial contouring consultations annually, with more than 68% opting for non-surgical contouring solutions. Learn about lip filler facts here.
Consumer demand for the shaping of jawlines accounts for 45%. The average improvement in the contour of the jawline after the use of high-concentration hyaluronic acid injections was 0.8 centimeters, with more smooth visual effects. In a 12-week follow-up, 87% of users reported that their facial lines were much clearer.
For professionals in this field, the price per milliliter of hyaluronic acid may be between 500 and 1,500 RMB, while an integral facial contouring project may be priced at 5,000 to 15,000 RMB. Relatively, the cost of a facial surgical operation is tens of thousands of RMB, and it requires 4 to 6 weeks to recover. The recovery cycle for non-surgical solutions is only 24-48 hours. More than 80% of users get injections before holidays.
The metabolic cycle of hyaluronic acid is usually 12 to 18 months, while botulinum toxin is metabolized in muscle tissue within 4 to 6 months. The combined therapy of hyaluronic acid and botulinum toxin improved facial laxity by approximately 40%, extending the effect duration by an average of 30%.
The side effect rate for hyaluronic acid injection is less than 1.2%, and most reactions are mild redness or itch that usually subsides within 48 hours. The post-operative infection rate in traditional surgeries exceeds 5%. In the Asian market, over 20% of the cases of surgical failures are due to infections.
More than 70% of users noted an improvement in overall facial proportions after adjustments in facial contouring. In general, the average injection volume is 3 milliliters per side for users with flatter faces, while 8 to 10 milliliters may be needed for severely unbalanced facial contours. A 3-milliliter injection resulted in a 22% improvement in visual facial projection, while a 6-milliliter injection produced a 35% improvement.
“Smart crosslinked hyaluronic acid” absorbs 20% more moisture compared to the traditional one. This technology extends the maintenance time of contouring results to over 24 months.
3D modeling and AI-assisted injection systems bring new changes. This technology enhanced injection satisfaction by 12%, the probability of redness within 24 hours was reduced by 15%, and over 42% of users increased the frequency of taking social media photos by 30% after a facial contouring injection.
Injected into Middle Dermis
About 30 million injection cases were performed worldwide in 2024, and 75% of those adopted the middle dermis injection method. 86% of participants reported that the skin texture improved significantly within 3 to 4 weeks after injection, with a reduction of fine lines by 30%. Learn more about undereye fillers here.
Hyaluronic acid molecules weighing between 1 million and 3 million Daltons can absorb up to 1,000 times their weight in water. In less than 48 hours after injection of 2 milliliters of hyaluronic acid, the skin moisture increased about 40% compared with only 10% when topical skin-care products were used. Fully 92% of users said skin fullness was improved after injection.
Every middle dermis injection costs between 3,000 to 6,000 RMB while one injection is from 1 to 3 milliliters. The average price for medical aesthetic surgeries is more than 20,000 RMB, recovery period of 2 to 4 weeks, and the recovery time of middle dermis injection is less than 48 hours. The repurchase rate of non-surgical injection reached 58%.
Metabolic cycle for hyaluronic acid injections is 12 to 18 months, while synthetic fillers can last over 24 months. 68% of users had maintained good skin elasticity and radiance 18 months after the first injection. 89% of the participants reported that their skin remained smooth and natural at expressions like smiling and frowning after the injection.
The side effect rate of hyaluronic acid’s injection in the middle dermis is below 1.5%. Most patients only had mild erythema and pruritus; generally, they resolve within 48 hours. The fat transplant and surgical filler post-operative infective risk could reach 5%, and some patients needed secondary repair. Among 200 cases of slight acne scar patients, skin texture improvement increased by 35% after injection.
Samples of the new crosslinked hyaluronic acid injections were kept at room temperature at 25°C for 72 hours without degrading, whereas products using traditional formulas maintain volume for just 48 hours.
The global non-surgical aesthetic market achieved an annual growth rate of 18% in 2024 and reached approximately 35% market share from middle dermis injection projects. Injection project consultations have been remarkably effective at a 22% year-over-year growth rate during the third quarter of 2023, with consultation and appointment rates reaching 1.5 times the usual level during wedding and holiday seasons.
Effective for Moderate to Severe Folds
Between 35 and 60 years, individuals develop up to 72% of moderate to severe wrinkles. With an average nasolabial fold, oral commissure lines, and tear troughs at 0.8 millimeters, severe lines develop at more than 1.2 millimeters. In application using non-surgical injection solutions, there was an approximate reduction of more than 85% of users recording a wrinkle depth reduction by around 35%, around 4-6 weeks after injection. Learn more about under-eye filler longevity here.
Hyaluronic acid in its molecular density of 1,500 to 2,500 Daltons is able to absorb more than 1,000 times its weight in water in the dermis layer. Following the injection of 2 milliliters of hyaluronic acid per side, the average reduction in visual depth of wrinkles was 0.5 millimeters, with up to 45% of the nasolabial folds deeper than 1 millimeter being reduced.
The price of hyaluronic acid injection is from 3,000 to 6,000 RMB per ml. A single case of wrinkle repair from moderate to serious usually costs between 8,000 to 15,000 RMB. Recovery time for surgery usually takes 2 to 4 weeks, though injection solutions only take 24 to 48 hours. During the past five years, the repurchase rate for such projects reached 62% of the total.
Generally speaking, the effect of wrinkle repair from a moderate to severe project lasts about 12-18 months in comparison with some low-molecular fillers, which last only about 6-9 months. The study conducted by 500 users showed that in 72%, good results after 12 months were maintained, while supplementary injections were required for less than 10%.
The results demonstrated that the multi-point injection techniques increased patients’ satisfaction after treatment by 15% and decreased the possibility of irregular absorption or lump formation by 10%.
The volume stability of the high-elasticity products was still 85% after 3,000 compressions, compared to only 60% in traditional products.
The rate of adverse reactions to hyaluronic acid injections is less than 1.2%, with symptoms usually subsiding within 48 hours. For surgical treatment solutions, adverse reaction rates exceed 5%. About 2% of facial surgery patients need secondary repairs every year, while the rate for hyaluronic acid injections is less than 0.5%.
After the injection of hyaluronic acid, the mean volume of the mid-face depression area of users above 40 years old increased to 1.2 milliliters, enhancing the degree of the projection by a degree of 22%. In addition, over 80% of patients experienced a better facial proportion balance after receiving treatment.
Within certain high-end medical aesthetic institutions that use 3D facial modeling technologies, satisfaction scores increase by a whopping 12% and reduced errors by 18% while improving general aesthetic appeal by more than 15% after injection.
In 2023, global market demand for moderate to severe wrinkle repair projects grew by 21% year-on-year. In the Asian region, over 1 million people undergo moderate to severe wrinkle repair injections annually, with 40% opting for injections before holidays. By 2026, the moderate to severe wrinkle repair market will reach a scale of $15 billion.
Long-Lasting Results
The average maintenance time of hyaluronic acid injection products is from 12 to 18 months, and for highly crosslinked hyaluronic acid products, this extends beyond 24 months. More than 78% of users retain facial fullness and elasticity up to the 12th month after the injection, while for ordinary fillers, a striking reduction in effect appeared between 6 and 9 months. Learn more about lip filler effects here.
A single injection of highly crosslinked hyaluronic acid usually costs between 8,000 and 15,000 RMB on average, while a low-concentration product is mostly sold at between 3,000 and 6,000 RMB. High-quality products require only one supplementation per year, while low-concentration fillers generally need replenishment every 6 to 8 months. More than 65% of users consider high-quality products to save money in the long run, reducing the expense of anti-aging by 20% each year.
Each milliliter of hyaluronic acid can absorb up to 1,000 times its weight in water. In areas with humidity below 40%, the skin’s moisture content in the hyaluronic acid injection area increased by an average of over 30%. This feature has driven an 18% growth in demand for highly crosslinked hyaluronic acid products in cold regions like North America and Europe.
Highly crosslinked hyaluronic acid has a metabolic rate in the skin that is 35% slower compared to ordinary products. Up to 72% of users maintained good skin conditions at the 18th month after their first injection.
Multi-layer injection techniques increased the post-injection feeling of fullness of vision by 25%, with a 4-6-month extension in the duration of effect. In China, South Korea, and Japan, the usage rates of multi-layer injection technology reached 42% each.
High-elasticity product injection sites could maintain 85% volume after 3,000 facial dynamic movements, while ordinary ones had only a volume retention rate of 60%.
The overall side effect rate from high-quality hyaluronic acid injections is less than 1.2%, and the majority of those present as mild redness or tenderness which settles in 48 hours. The nodule formation rate of traditional fillers in scenarios of high-density injections is about 3%.
Over 80% of users reduced repeated injections after experiencing high-performance products, and after trying highly crosslinked hyaluronic acid injections, 52% recommended the same projects to friends and family. In addition, the repurchase rate of long-acting products increased by 21% year on year, while appointments during weddings and holidays are 35% higher than usual.
In 2023, a biotechnology company introduced an “ultra-stable” hyaluronic acid product, with its biodegradation rate being 40% lower compared to traditional products, maintaining shape stability in high-temperature environments for up to 72 hours.
